Therametric Technologies, Inc. was established in 1996 by two faculty members (Drs. Mostafa Analoui and Mark Saxen) at the Indiana University School of Dentistry and was acquired by Dr. George K. Stookey in July 2002. It was housed in leased space located within the Indiana University Emerging Technologies Center on the Indiana University – Purdue University at Indianapolis campus through March 2010. Since April 2010, the company is housed in its own new 26,000 square foot facility located near Noblesville, Indiana. Facilities include dental research laboratories; a dental clinic; product manufacturing, testing, packaging, and shipping areas; staff offices; and various support facilities.

Available research instrumentation includes a variety of instruments designed for dental caries detection and the conduct of controlled clinical trials. Available analytical instruments include a Perkin Elmer atomic absorption spectrometer, a Packard 2900TR tri carb liquid scintillation analyzer, two Leco LM247AT microhardness testers, enamel polishing instruments, Mettler analytical balances, an IEC Multi centrifuge, an Accumet AR10 ph meter, conventional and ultrasonic water baths, vacuum pumps, a vacuum oven, Ohaus top loading balances, a Thomas Scientific metallurgical microscope, an incubator, drying ovens, magnetic stirrers, mechanical stirrers, a Klett colorimeter, a variety of Pipetman instruments, and conventional types of laboratory glassware and plasticware.

TTI is staffed by a combination of full-time and part-time employees with expertise in dentistry and dental research as well as administrative support.